Article Text

Download PDFPDF

NEUROLOGICAL ASPECTS OF TROPICAL DISEASE
Cerebral malaria
Free
  1. Charles R J C Newtona,
  2. Tran Tinh Hienb,
  3. Nicholas Whiteb,c
  1. aNeurosciences Unit, Institute of Child Health, London, United Kingdom, bCentre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Vietnam, cFaculty of Tropical Medicine, Mahidol University, Bangkok, Thialand
  1. Dr C R J C Newton, Wellcome Trust/ KEMRI Centre, PO Box 230, Kilifi, Kenyacnewton{at}kilifi.mimcom.net

Abstract

Cerebral malaria may be the most common non-traumatic encephalopathy in the world. The pathogenesis is heterogenous and the neurological complications are often part of a multisystem dysfunction. The clinical presentation and pathophysiology differs between adults and children. Recent studies have elucidated the molecular mechanisms of pathogenesis and raised possible interventions. Antimalarial drugs, however, remain the only intervention that unequivocally affects outcome, although increasing resistance to the established antimalarial drugs is of grave concern. Artemisinin derivatives have made an impact on treatment, but other drugs may be required. With appropriate antimalarial drugs, the prognosis of cerebral malaria often depends on the management of other complications—for example, renal failure and acidosis. Neurological sequelae are increasingly recognised, but further research on the pathogenesis of coma and neurological damage is required to develop other ancillary treatments.

  • malaria
  • antimalarial drugs
  • coma
  • parasitic disease
View Full Text

Statistics from Altmetric.com

Footnotes

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.