Article Text
Statistics from Altmetric.com
In the December issue of this JournalLawden et al 1 found in an adult population receiving vigabatrin (VGB), mostly in association with other antiepileptic drugs, a high prevalence (52%) of visual field defects. These abnormalities were not reversible after discontinuation of VGB therapy.
Since 1990, several authors have reported circumferential narrowing of the visual field with characteristic temporal sparing in patients treated with VGB. Although a visual field defect is the most common cause for discontinuation of VGB therapy, no conclusive data are presently available to explain the pathogenesis of this major side effect.1 2 Interestingly, retinal dysfunction has been primarily described in patients receiving VGB in combination with other antiepileptic drugs, whereas only a few cases have been reported in patients treated with VGB as a monotherapy.2 Despite increasing …