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Early detection of non-compliance in Wilson's disease by consecutive copper determination in cerebrospinal fluid
  1. Neurological Department, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
  1. Dr H J Stuerenburg stuerenburg{at}

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A 41 year old technical employee was diagnosed with Wilson's disease in 1982, 2 years after onset of dysarthria, diplopia, visual deficits, ataxia, and concentration deficits. The patient improved rapidly with d-penicillamine and a copper free diet, and has since returned to normal neurological function. Penicillamine was stopped in 1989 and he changed his diet from copper free to a normal diet in 1987. In 1990 he was put on 800 mg zinc a day. During the past 17 years he underwent 20 determinations of copper concentration in CSF for …

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