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Magnetisation transfer analysis and the disability resulting from multiple sclerosis
  1. S A HAWKINS
  1. Institute of Clinical Science
  2. The Queen's University of Belfast
  3. Room 125, Mulhouse Building
  4. Grosvenor Road, Belfast BT12 6BJ
  5. Northern Ireland, UK
  1. s.hawkins{at}qub.ac.uk

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Over the past 20 years MRI techniques have given wonderful insights into the pathogenesis of multiple sclerosis. We have learned how lesions evolve and resolve, that measures of neuronal and axonal loss show that multiple sclerosis is not just a disease of myelin, and that over time the brain atrophies. The suspicion that the normal appearing white cell matter between the lesions of multiple sclerosis is abnormal has been confirmed. The contribution of MRI to clinical trials of novel therapeutic agents has been decisive …

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