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  • Diagnosis of a multifocal B cell lymphoma with preceding demyelinating central nervous system lesions by single voxel proton MR spectroscopy

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Diagnosis of a multifocal B cell lymphoma with preceding demyelinating central nervous system lesions by single voxel proton MR spectroscopy
  1. T Kuhlmanna,
  2. A Schröterb,
  3. P Dechente,
  4. F Weberb,
  5. H H Rustenbeckc,
  6. L Füzesid,
  7. W Brücka,
  8. H Ehrenreichb,
  9. J Frahme
  1. aDepartment of Neuropathology, Georg-August- University, Göttingen, Germany, bDepartment of Neurology, cDepartment of Neuroradiology, dDepartment of Pathology, eBiomedizinische NMR Forschungs GmbH, Am Faβberg 11, Max-Planck-Institut für Biophysikalische Chemie, 37077 Göttingen, Germany
  1. Professor J Frahmjfrahm{at}gwdg.de

Abstract

Single voxel proton magnetic resonance spectroscopy (MRS) provides a rapid non-invasive fingerprint of tissue chemistry. A case history is presented in which a B cell lymphoma with antecedent demyelinating lesions of the CNS was suspected by MRS and confirmed by neuropathological examination and immunoglobulin gene rearrangement.

  • CNS lymphoma
  • magnetic resonance spectroscopy
  • demyelination

https://doi.org/10.1136/jnnp.70.2.259

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