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  • Atypical form of dural graft associated Creutzfeldt-Jakob disease: report of a postmortem case with review of the literature

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Atypical form of dural graft associated Creutzfeldt-Jakob disease: report of a postmortem case with review of the literature
  1. K Kimuraa,
  2. A Nonakab,
  3. H Tashirob,
  4. M Yaginumab,
  5. R Shimokawac,
  6. R Okedac,
  7. M Yamadad
  1. aDepartment of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan, bDepartment of Internal Medicine, cDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan, dDepartment of Neurology, Kanazawa University School of Medicine, 13–1 Takara-machi, Kanazawa 920–8640, Japan
  1. Professor M Yamadam-yamada{at}med.kanazawa-u.ac.jp

Abstract

A postmortem case of an atypical form of dural graft associated Creutzfeldt-Jakob disease (CJD) is described. A 42 year old man developed progressive spastic paresis 163 months after a cadaveric dura mater graft. He presented with no myoclonus and very late occurrence of periodic synchronous discharges on EEG. The prion protein (PrP) gene was homozygous for methionine at the polymorphic codon 129. Neuropathological examination disclosed plaque-like PrP deposits with atypical distribution of synaptic PrP accumulations in the brain. This patient represents an atypical form of dural graft associated CJD characterised by unusual clinicopathological features.

  • cadaveric dura mater graft
  • Creutzfeldt-Jakob disease
  • prion protein
  • plaque

https://doi.org/10.1136/jnnp.70.5.696

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