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Alcohol consumption and frontal lobe shrinkage: study of 1432 non-alcoholic subjects
  1. M Kubotaa,
  2. S Nakazakia,
  3. S Hiraia,
  4. N Saekia,
  5. A Yamauraa,
  6. T Kusakab
  1. aDepartment Neurosurgery, Chiba University School of Medicine, Inohana 1–8–1, Chuo-ku, Chiba-shi, Chiba, 260–8670 Japan, bKusaka Clinic
  1. Dr M Kubotakubota{at}med.m.chiba-u.ac.jp

Abstract

OBJECTIVES To evaluate the influences of chronic alcohol consumption on brain volume among social drinkers, as it is well known that alcohol misusers have a high risk of brain shrinkage.

METHODS Frontal lobe volumes on MRI were compared with the current alcohol habits of consecutive 1432 non-alcoholic subjects.

RESULTS After adjusting for other variables, age was found to be the most powerful promoting factor for the shrinkage with a odds ratio of 2.8 (95% confidence interval (95% CI) 1.23–3.06) for each 10 years of age. Regarding alcohol habit, 667 of the subjects were abstainers, and 157, 362, and 246 of the subjects were light (average 88.2 g ethanol/week), moderate (181.2 g/week), and heavy (418.1 g/week) drinkers, respectively. Moderate alcohol consumption did not increase the incidence of frontal lobe shrinkage (odds ratio 0.98; 95% CI 0.73–1.33), whereas heavy drinkers were at a higher risk compared with abstainers (1.80; 1.32–2.46). The contributory rate of alcohol consumption for frontal lobe shrinkage was 11.3%.

CONCLUSION The brain tends to shrink physiologically with age. Heavy alcohol consumption seems to exaggerate this shrinkage in social drinkers. Moderate alcohol consumption does not seem to affect brain volume.

  • alcohol
  • social drinker
  • brain atrophy

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