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Efficacy of high dose steroid therapy in children with severe acute transverse myelitis
  1. P Defresnea,
  2. L Meyerc,
  3. M Tardieuc,
  4. E Scalaisd,
  5. C Nuttine,
  6. B De Bontf,
  7. G Loftusg,
  8. P Landrieuc,
  9. H Kadhima,b,
  10. G Sébirea
  1. aService de Neurologie, Département de Pédiatrie, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, 1200 Bruxelles, Belgium, bUnité de Neuropathologie, Service d'Anatomopathologie, CHU Brugmann-HUDERF, ULB, Bruxelles, Belgium, cService de Neurologie, Département de Pédiatrie et INSERM U292, Service d'Epidémiologie, Hôpital de Bicêtre, Université Paris XI, Le Kremlin-Bicêtre, France, dService de Pédiatrie, Clinique de l'Espérance, Montegnée, Belgium, eService de Pédiatrie, Centre Hospitalier de Luxembourg, Luxembourg, fService de Pédiatrie, Clinique de Jolimont, La Louvière, Belgium, gPediatric Department, Galway University Hospital, University of Galway, Galway, Ireland
  1. Dr P Defresnepierre.defresne{at}freebel.net

Abstract

No effective treatment has been demonstrated for patients with acute transverse myelopathy. In a multicentre controlled study, 12 children with severe acute transverse myelopathy were treated with intravenous methylprednisolone (IVMP) and compared with a historical group of 17 patients. The treatment had a significant effect on the proportion of patients walking independently at 1 month and on the proportion with full recovery at 1 year, with no differences in the frequency of complications between the two groups.

  • steroids: acute transverse myelopathy: encephalomyelitis

https://doi.org/10.1136/jnnp.71.2.272

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