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In the paper by Du et al (this issue, pp441–447)1 an evaluation of the entorhinal cortex (ERC), hippocampus (HP), and total brain tissue volumes was conducted in controls, patients with Alzheimer's disease, and non-demented subjects with a clinical dementia rating (CDR) score of 0.5 implicating mild memory impairment. Although the major finding of the study was that the HP and ERC were significantly reduced in volume for the CDR 0.5 group compared with controls, there was a large degree of overlap between the two groups and the sensitivity and specificity of correctly classifying the two groups were not improved when ERC volumes were added to HP measures alone. Postmortem studies of those with mild memory impairment and early Alzheimer's disease have implicated the ERC as the first site to carry the …