The impetus for this book has arisen from an annual magnetic resonance course which brings together some of the outstanding con- tributors in the field of magnetic resonance techniques as applied to multiple sclerosis. Magnetic resonance spectroscopy (MRS) is one of a handful of relatively new MR techniques which have proved particularly useful in trying to clarify the pathophysiology of multiple sclerosis. The greatest achievement of MRS in this field has been to provide highly persuasive evidence that axonal loss is likely to be the key determinant in the development …