Efficacy and safety of modafinil (Provigil®) for the treatment of fatigue in multiple sclerosis: a two centre phase 2 study

K W Rammohan; J H Rosenberg; D J Lynn; A M Blumenfeld; C P Pollak; H N Nagaraja

doi:10.1136/jnnp.72.2.179

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Efficacy and safety of modafinil (Provigil^®) for the treatment of fatigue in multiple sclerosis: a two centre phase 2 study

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Online download statistics by month: January 2002 to March 2023

	Abstract	Full	Pdf
Jan 2002	378	418	86
Feb 2002	264	346	74
Mar 2002	140	252	36
Apr 2002	62	160	42
May 2002	40	117	38
Jun 2002	16	77	15
Jul 2002	16	82	37
Aug 2002	24	65	26
Sep 2002	39	74	15
Oct 2002	27	60	18
Nov 2002	11	52	31
Dec 2002	25	47	12
Jan 2003	23	63	14
Feb 2003	26	60	50
Mar 2003	28	46	37
Apr 2003	35	48	41
May 2003	21	41	49
Jun 2003	23	53	38
Jul 2003	12	50	57
Aug 2003	8	42	32
Sep 2003	18	45	25
Oct 2003	18	48	22
Nov 2003	17	35	27
Dec 2003	14	42	42
Jan 2004	12	51	47
Feb 2004	16	61	63
Mar 2004	17	48	40
Apr 2004	33	59	45
May 2004	19	52	48
Jun 2004	25	73	61
Jul 2004	80	94	39
Aug 2004	64	102	59
Sep 2004	65	81	57
Oct 2004	59	121	71
Nov 2004	55	168	65
Dec 2004	42	108	50
Jan 2005	60	87	57
Feb 2005	57	143	47
Mar 2005	55	130	95
Apr 2005	36	141	62
May 2005	39	117	70
Jun 2005	82	121	49
Jul 2005	69	125	43
Aug 2005	68	88	43
Sep 2005	67	84	45
Oct 2005	83	81	59
Nov 2005	89	138	39
Dec 2005	83	116	40
Jan 2006	70	152	44
Feb 2006	58	221	46
Mar 2006	66	215	44
Apr 2006	102	158	33
May 2006	196	101	38
Jun 2006	138	71	32
Jul 2006	140	77	37
Aug 2006	104	71	39
Sep 2006	126	143	59
Oct 2006	143	132	65
Nov 2006	138	103	47
Dec 2006	112	83	45
Jan 2007	114	100	50
Feb 2007	128	125	77
Mar 2007	153	145	70
Apr 2007	217	10	21
May 2007	203	22	30
Jun 2007	139	21	24
Jul 2007	163	46	33
Aug 2007	164	18	25
Sep 2007	189	27	32
Oct 2007	159	13	14
Nov 2007	163	21	22
Dec 2007	571	29	27
Jan 2008	204	22	27
Feb 2008	214	17	24
Mar 2008	191	24	29
Apr 2008	262	23	31
May 2008	174	13	13
Jun 2008	186	5	11
Jul 2008	224	16	25
Aug 2008	187	16	13
Sep 2008	160	9	9
Oct 2008	159	18	24
Nov 2008	134	18	20
Dec 2008	139	17	15
Jan 2009	150	11	20
Feb 2009	166	23	22
Mar 2009	187	22	30
Apr 2009	158	18	22
May 2009	148	24	23
Jun 2009	122	13	14
Jul 2009	121	8	13
Aug 2009	131	21	17
Sep 2009	133	13	9
Oct 2009	125	7	6
Nov 2009	97	8	4
Dec 2009	132	16	0
Jan 2010	128	21	0
Feb 2010	180	45	0
Mar 2010	209	42	0
Apr 2010	181	51	0
May 2010	134	32	0
Jun 2010	89	28	0
Jul 2010	100	21	0
Aug 2010	88	29	0
Sep 2010	80	27	0
Oct 2010	81	24	0
Nov 2010	88	13	0
Dec 2010	71	10	0
Jan 2011	82	18	0
Feb 2011	108	28	0
Mar 2011	86	18	0
Apr 2011	77	34	0
May 2011	72	18	0
Jun 2011	68	13	0
Jul 2011	77	16	0
Aug 2011	75	33	0
Sep 2011	79	27	0
Oct 2011	127	23	0
Nov 2011	113	54	0
Dec 2011	70	51	0
Jan 2012	98	70	0
Feb 2012	64	41	0
Mar 2012	86	62	0
Apr 2012	108	66	0
May 2012	86	108	0
Jun 2012	99	86	0
Jul 2012	115	77	0
Aug 2012	108	66	0
Sep 2012	82	59	0
Oct 2012	94	56	0
Nov 2012	105	75	0
Dec 2012	106	66	0
Jan 2013	131	92	0
Feb 2013	124	95	0
Mar 2013	134	111	0
Apr 2013	136	123	0
May 2013	107	223	0
Jun 2013	94	146	0
Jul 2013	95	114	0
Aug 2013	73	88	0
Sep 2013	70	106	0
Oct 2013	104	124	0
Nov 2013	100	136	0
Dec 2013	84	101	0
Jan 2014	57	148	0
Feb 2014	77	85	0
Mar 2014	125	146	0
Apr 2014	106	155	0
May 2014	88	207	0
Jun 2014	96	143	0
Jul 2014	71	87	0
Aug 2014	56	82	0
Sep 2014	107	114	0
Oct 2014	146	141	0
Nov 2014	113	78	0
Dec 2014	84	52	0
Jan 2015	132	104	0
Feb 2015	109	60	0
Mar 2015	123	146	0
Apr 2015	98	125	0
May 2015	140	140	0
Jun 2015	118	104	0
Jul 2015	126	160	0
Aug 2015	121	130	0
Sep 2015	283	142	2
Oct 2015	115	97	8
Nov 2015	176	162	16
Dec 2015	164	189	18
Jan 2016	144	165	11
Feb 2016	150	177	21
Mar 2016	138	172	25
Apr 2016	217	199	27
May 2016	168	185	29
Jun 2016	129	148	13
Jul 2016	148	224	14
Aug 2016	102	123	16
Sep 2016	110	128	19
Oct 2016	139	144	26
Nov 2016	148	120	18
Dec 2016	100	195	21
Jan 2017	122	192	13
Feb 2017	74	253	29
Mar 2017	58	288	37
Apr 2017	59	159	42
May 2017	85	100	23
Jun 2017	64	87	21
Jul 2017	115	64	17
Aug 2017	164	72	17
Sep 2017	168	86	16
Oct 2017	206	125	19
Nov 2017	221	136	33
Dec 2017	171	101	15
Jan 2018	244	145	17
Feb 2018	296	173	18
Mar 2018	286	183	22
Apr 2018	259	145	18
May 2018	261	145	24
Jun 2018	206	137	10
Jul 2018	166	98	35
Aug 2018	193	141	21
Sep 2018	187	128	34
Oct 2018	239	143	25
Nov 2018	192	118	17
Dec 2018	141	91	22
Jan 2019	144	105	27
Feb 2019	159	119	31
Mar 2019	198	153	36
Apr 2019	227	176	44
May 2019	235	141	37
Jun 2019	189	121	33
Jul 2019	214	143	36
Aug 2019	222	170	36
Sep 2019	192	151	25
Oct 2019	265	177	21
Nov 2019	235	152	28
Dec 2019	212	139	11
Jan 2020	240	172	19
Feb 2020	271	201	30
Mar 2020	178	133	14
Apr 2020	167	90	17
May 2020	158	101	17
Jun 2020	158	107	17
Jul 2020	132	94	28
Aug 2020	136	96	23
Sep 2020	168	125	27
Oct 2020	260	201	30
Nov 2020	202	145	29
Dec 2020	269	197	22
Jan 2021	406	357	34
Feb 2021	276	240	25
Mar 2021	313	278	21
Apr 2021	319	274	27
May 2021	329	302	27
Jun 2021	199	200	20
Jul 2021	297	306	19
Aug 2021	294	295	21
Sep 2021	326	325	17
Oct 2021	350	314	47
Nov 2021	233	196	43
Dec 2021	347	312	19
Jan 2022	338	293	19
Feb 2022	289	257	21
Mar 2022	464	432	42
Apr 2022	403	359	41
May 2022	425	374	26
Jun 2022	315	271	27
Jul 2022	368	318	28
Aug 2022	448	416	23
Sep 2022	455	415	28
Oct 2022	360	316	41
Nov 2022	317	272	25
Dec 2022	325	301	23
Jan 2023	465	410	35
Feb 2023	390	363	28
Total	37669	30057	5727

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