Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease

O L Lopez; J T Becker; S Wisniewski; J Saxton; D I Kaufer; S T DeKosky

doi:10.1136/jnnp.72.3.310

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Original Article

Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease

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	Abstract	Full	Pdf
Feb 2002	348	181	83
Mar 2002	291	276	96
Apr 2002	346	211	56
May 2002	77	96	50
Jun 2002	27	64	21
Jul 2002	11	55	13
Aug 2002	14	45	22
Sep 2002	15	42	9
Oct 2002	22	52	12
Nov 2002	16	59	28
Dec 2002	9	34	9
Jan 2003	18	63	15
Feb 2003	33	35	13
Mar 2003	15	39	42
Apr 2003	8	28	17
May 2003	7	32	41
Jun 2003	6	34	29
Jul 2003	6	30	29
Aug 2003	8	31	17
Sep 2003	6	22	25
Oct 2003	8	33	13
Nov 2003	7	27	29
Dec 2003	1	12	23
Jan 2004	8	22	20
Feb 2004	7	24	29
Mar 2004	13	30	24
Apr 2004	9	36	23
May 2004	10	30	30
Jun 2004	13	31	30
Jul 2004	56	79	38
Aug 2004	65	72	26
Sep 2004	46	82	40
Oct 2004	40	61	49
Nov 2004	30	70	27
Dec 2004	55	91	21
Jan 2005	36	68	16
Feb 2005	33	76	39
Mar 2005	62	58	26
Apr 2005	46	56	36
May 2005	37	62	33
Jun 2005	22	38	35
Jul 2005	18	49	30
Aug 2005	23	54	35
Sep 2005	33	55	32
Oct 2005	26	76	34
Nov 2005	16	50	29
Dec 2005	18	48	19
Jan 2006	22	72	36
Feb 2006	22	84	27
Mar 2006	25	101	47
Apr 2006	25	76	40
May 2006	36	45	30
Jun 2006	49	22	23
Jul 2006	35	24	20
Aug 2006	36	34	20
Sep 2006	39	40	34
Oct 2006	64	55	35
Nov 2006	64	65	46
Dec 2006	52	36	33
Jan 2007	45	40	43
Feb 2007	46	51	25
Mar 2007	72	43	33
Apr 2007	58	12	18
May 2007	41	12	22
Jun 2007	36	11	19
Jul 2007	32	11	13
Aug 2007	31	5	7
Sep 2007	46	5	11
Oct 2007	61	22	17
Nov 2007	58	12	15
Dec 2007	47	12	10
Jan 2008	54	18	11
Feb 2008	54	13	26
Mar 2008	75	15	22
Apr 2008	51	6	12
May 2008	46	9	18
Jun 2008	28	2	4
Jul 2008	28	2	2
Aug 2008	27	5	7
Sep 2008	41	7	7
Oct 2008	54	4	11
Nov 2008	53	14	13
Dec 2008	29	6	6
Jan 2009	29	10	9
Feb 2009	44	6	10
Mar 2009	59	12	19
Apr 2009	53	3	8
May 2009	43	2	6
Jun 2009	28	4	15
Jul 2009	41	7	7
Aug 2009	27	3	3
Sep 2009	36	4	7
Oct 2009	48	2	11
Nov 2009	70	7	12
Dec 2009	35	5	8
Jan 2010	37	3	6
Feb 2010	59	8	8
Mar 2010	84	10	10
Apr 2010	58	16	11
May 2010	44	14	8
Jun 2010	29	12	10
Jul 2010	36	2	7
Aug 2010	41	4	5
Sep 2010	49	9	7
Oct 2010	48	6	4
Nov 2010	68	9	12
Dec 2010	45	2	9
Jan 2011	42	1	7
Feb 2011	57	16	13
Mar 2011	67	11	13
Apr 2011	58	1	5
May 2011	43	13	13
Jun 2011	41	3	4
Jul 2011	22	5	1
Aug 2011	37	0	4
Sep 2011	46	3	3
Oct 2011	58	15	22
Nov 2011	61	40	5
Dec 2011	39	26	10
Jan 2012	20	30	14
Feb 2012	36	40	11
Mar 2012	46	26	15
Apr 2012	42	23	14
May 2012	30	23	13
Jun 2012	35	20	9
Jul 2012	31	16	15
Aug 2012	26	15	7
Sep 2012	45	35	28
Oct 2012	53	29	34
Nov 2012	62	31	22
Dec 2012	42	14	13
Jan 2013	42	37	22
Feb 2013	74	33	32
Mar 2013	61	39	33
Apr 2013	39	31	27
May 2013	42	16	21
Jun 2013	23	12	13
Jul 2013	26	14	15
Aug 2013	33	11	17
Sep 2013	34	15	18
Oct 2013	49	23	17
Nov 2013	61	27	30
Dec 2013	50	18	25
Jan 2014	21	11	14
Feb 2014	39	14	25
Mar 2014	58	33	21
Apr 2014	72	15	64
May 2014	45	21	36
Jun 2014	63	24	20
Jul 2014	47	29	21
Aug 2014	44	14	17
Sep 2014	42	12	19
Oct 2014	56	19	20
Nov 2014	69	26	19
Dec 2014	50	5	11
Jan 2015	62	13	4
Feb 2015	52	8	24
Mar 2015	53	23	27
Apr 2015	64	17	20
May 2015	48	11	10
Jun 2015	26	12	8
Jul 2015	27	17	6
Aug 2015	28	10	10
Sep 2015	38	14	10
Oct 2015	30	12	5
Nov 2015	49	20	19
Dec 2015	47	17	21
Jan 2016	46	21	21
Feb 2016	47	28	20
Mar 2016	45	26	17
Apr 2016	47	24	8
May 2016	38	22	16
Jun 2016	31	11	7
Jul 2016	34	17	8
Aug 2016	40	9	5
Sep 2016	28	18	8
Oct 2016	58	25	16
Nov 2016	79	24	20
Dec 2016	51	13	11
Jan 2017	39	20	5
Feb 2017	32	19	16
Mar 2017	46	49	22
Apr 2017	41	37	9
May 2017	40	19	14
Jun 2017	14	26	14
Jul 2017	26	18	10
Aug 2017	29	15	5
Sep 2017	29	17	6
Oct 2017	42	22	11
Nov 2017	60	36	10
Dec 2017	49	21	8
Jan 2018	45	31	6
Feb 2018	130	44	9
Mar 2018	86	30	15
Apr 2018	210	79	18
May 2018	90	45	13
Jun 2018	56	28	8
Jul 2018	60	14	11
Aug 2018	41	21	12
Sep 2018	71	33	17
Oct 2018	135	87	17
Nov 2018	112	54	22
Dec 2018	110	64	24
Jan 2019	101	41	249
Feb 2019	92	45	223
Mar 2019	148	29	264
Apr 2019	122	30	205
May 2019	97	21	233
Jun 2019	51	13	267
Jul 2019	69	18	176
Aug 2019	46	12	177
Sep 2019	77	17	298
Oct 2019	151	33	284
Nov 2019	119	30	182
Dec 2019	136	22	189
Jan 2020	158	24	145
Feb 2020	124	36	28
Mar 2020	116	24	20
Apr 2020	98	18	25
May 2020	120	33	13
Jun 2020	98	14	15
Jul 2020	64	20	15
Aug 2020	46	8	22
Sep 2020	97	37	9
Oct 2020	136	36	23
Nov 2020	122	23	19
Dec 2020	107	44	13
Jan 2021	65	24	19
Feb 2021	66	16	18
Mar 2021	69	11	12
Apr 2021	84	21	26
May 2021	70	21	25
Jun 2021	18	18	15
Jul 2021	14	14	13
Aug 2021	22	22	19
Sep 2021	27	27	26
Oct 2021	88	36	53
Nov 2021	52	20	39
Dec 2021	37	21	13
Jan 2022	43	18	17
Feb 2022	51	32	13
Mar 2022	86	34	28
Apr 2022	65	23	18
May 2022	58	35	23
Jun 2022	62	44	12
Jul 2022	49	36	21
Aug 2022	53	41	11
Sep 2022	60	37	26
Oct 2022	100	49	32
Nov 2022	77	41	16
Dec 2022	53	28	5
Jan 2023	57	41	9
Feb 2023	69	54	8
Mar 2023	57	33	6
Apr 2023	39	21	17
May 2023	37	25	13
Jun 2023	43	25	9
Jul 2023	54	28	12
Aug 2023	45	17	17
Sep 2023	41	22	15
Oct 2023	37	24	6
Nov 2023	72	33	11
Dec 2023	118	14	9
Jan 2024	104	1	3
Feb 2024	43	0	1
Mar 2024	99	2	1
Total	14333	7783	7594

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