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Herpes simplex encephalitis
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  • Published on:
    Authors' reply

    Dear Editor

    Dr McCorry makes an intriguing point that has indeed occurred to us before. It is theoretically possible that a positive PCR HSV result in the CSF could reflect asymptomatic HSV latency in the sensory ganglia and/or CNS and not viral reactivation causing encephalitis. However, it would be difficult to explain how the virus reaches the CSF from the ganglia or brain in the absence of reactivation. Also, i...

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    Conflict of Interest:
    None declared.
  • Published on:
    Does a positive HSV PCR neccesarily mean Herpes Simplex encephalitis?

    Dear Editor

    The assumption is that if PCR for HSV in the CSF is positive this then confirms the diagnosis of Herpes Simplex Encephalitis, yet it is known that the HSV genome is found in 85-90% of patients at unselected necroscopy in the trigeminal ganglion and so do we know whether HSV DNA can be found in healthy individuals? Could it be that some positive PCR results are truely positive, and not due to con...

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    Conflict of Interest:
    None declared.