Article Text

Download PDFPDF
Multiple Sclerosis Impact Scale (MSIS-29): reliability and validity in hospital based samples
  1. A Riazi1,
  2. J C Hobart1,2,
  3. D L Lamping3,
  4. R Fitzpatrick4,
  5. A J Thompson1
  1. 1Neurological Outcome Measures Unit, Institute of Neurology, London, UK
  2. 2Department of Clinical Neurosciences, Derriford Hospital, Devon, UK
  3. 3Health Services Research Unit, London School of Hygiene and Tropical Medicine, UK
  4. 4Department of Public Health and Primary Care, University of Oxford, UK
  1. Correspondence to:
 Dr J Hobart, Department of Clinical Neurosciences, Derriford Hospital, Plymouth, Devon PL8 8DH, UK;


Background and aim: The psychometric properties of rating scales are sample dependent and need evaluations in different samples. The Multiple Sclerosis Impact Scale (MSIS-29), a new patient based rating scale for multiple sclerosis (MS) was predominantly developed from a community based sample derived from the MS Society. A number of important patient characteristics of this sample remain unknown. The aim of the study was to evaluate five psychometric properties of the MSIS-29 in three hospital based samples: people admitted for rehabilitation, people admitted for intravenous corticosteroid treatment for MS relapses, and people with primary progressive MS.

Methods: People with MS were recruited from the three clinical settings. They completed several health measures. MSIS-29 data were evaluated for data quality, scaling assumptions, acceptability, reliability and validity, and compared with those from a previously reported community based study.

Results: A total of 233 people (rehabilitation =53; corticosteroids =76; primary progressive =104) completed questionnaires. In all samples, missing data were low (≤2.2%), scaling assumptions were satisfied, and reliability was high (≥0.91). Correlations between the MSIS-29 and other scales were consistent with a priori hypotheses. Findings were consistent with those from the community samples.

Conclusions: The psychometric properties of the MSIS-29 are consistent across three hospital based samples, and similar to those in the community samples. These findings further support its use as an outcome measure in different clinical settings.

  • multiple sclerosis
  • Multiple Sclerosis Impact Scale (MSIS-29)
  • health outcomes measurement
  • psychometric methods
  • MS, multiple sclerosis
  • MSIS-29, Multiple Sclerosis Impact Scale

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests: none declared.