Article Text

Download PDFPDF
Diffuse brain oedema in idiopathic intracranial hypertension: a quantitative magnetic resonance imaging study
  1. M E Bastin1,
  2. S Sinha2,
  3. A J Farrall2,
  4. J M Wardlaw2,
  5. I R Whittle2
  1. 1Medical and Radiological Sciences (Medical Physics), University of Edinburgh, Edinburgh, UK
  2. 2Clinical Neurosciences, University of Edinburgh
  1. Correspondence to:
 Dr Mark Bastin
 Medical and Radiological Sciences (Medical Physics), University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK;


Objectives: To investigate the hypothesis that idiopathic intracranial hypertension is associated with diffuse brain oedema, using quantitative magnetic resonance imaging.

Methods: Values for the mean diffusivity of water (<D>) and the proton longitudinal relaxation time (T1) were measured for various brain regions in 10 patients with idiopathic intracranial hypertension and 10 age, sex, and weight matched controls.

Results: No significant differences in <D> and T1 values were found between patient and control groups in any of the brain regions investigated.

Conclusions: The results suggest that idiopathic intracranial hypertension is not associated with abnormalities of convective transependymal water flow leading to diffuse brain oedema.

  • idiopathic intracranial hypertension
  • magnetic resonance imaging
  • diffusion
  • proton longitudinal relaxation time
  • ADC, apparent diffusion coefficient
  • DW-MRI, diffusion weighted magnetic resonance imaging
  • EP, echo planar
  • IIH, idiopathic intracranial hypertension
  • IR, inversion recovery
  • ROI, region of interest
  • TI, inversion time

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests: none declared