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Intracerebral microdialysis and CSF hydrodynamics in idiopathic adult hydrocephalus syndrome
  1. A Ågren-Wilsson1,
  2. M Roslin1,
  3. A Eklund2,
  4. L-O D Koskinen1,
  5. A T Bergenheim1,
  6. J Malm1
  1. 1Department of Clinical Neuroscience, Umeå University, Umeå, Sweden
  2. 2Department of Biomedical Engineering and Informatics, Umeå University
  1. Correspondence to:
    Aina Ågren-Wilsson, Department of Clinical Neuroscience, Umeå University, S-901 85 Umeå, Sweden;
    aina.agren.wilsson{at}neuro.umu.se

Abstract

Background: In idiopathic adult hydrocephalus syndrome (IAHS), a pathophysiological model of “chronic ischaemia” caused by an arteriosclerotic process in association with a CSF hydrodynamic disturbance has been proposed.

Objective: To investigate whether CSF hydrodynamic manipulation has an impact on biochemical markers related to ischaemia, brain tissue oxygen tension (Ptio2), and intracranial pressure.

Methods: A microdialysis catheter, a Ptio2 probe, and an intracerebral pressure catheter were inserted into the periventricular white matter 0–7 mm from the right frontal horn in 10 patients with IAHS. A subcutaneous microdialysis probe was used as reference. Intracranial pressure and intracerebral Ptio2 were recorded continuously. Samples were collected for analysis between 2 and 4 pm on day 1 (baseline) and at the same time on day 2, two to four hours after a lumbar CSF hydrodynamic manipulation. The concentrations of glucose, lactate, pyruvate, and glutamate on day 1 and 2 were compared.

Results: After CSF drainage, there was a significant rise in the intracerebral concentration of lactate and pyruvate. The lactate to pyruvate ratio was increased and remained unchanged after drainage. There was a trend towards a lowering of glucose and glutamate. Mean intracerebral Ptio2 was higher on day 2 than on day 1 in six of eight patients.

Conclusions: There is increased glucose metabolism after CSF drainage, as expected in a situation of postischaemic recovery. These new invasive techniques are promising tools in the future study of the pathophysiological processes in IAHS.

  • normal pressure hydrocephalus
  • microdialysis
  • brain tissue oxygen tension

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