Article Text
Paper
Improvement of central motor conduction after bone marrow transplantation in adrenoleukodystrophy
Abstract
The case is described of a 20 year old man with adrenoleukodystrophy who showed right spastic hemiparesis and gait disturbance. Brain magnetic resonance imaging disclosed predominant involvement of the left corticospinal pathway. The clinical symptoms improved after bone marrow transplantation. Transcranial magnetic stimulation disclosed significant improvement in various parameters of central motor conduction.
- adrenoleukodystrophy
- bone marrow transplantation
- transcranial magnetic stimulation
- ALD, adrenoleukodystrophy
- BAEP, brain stem auditory evoked potential
- BMT, bone marrow transplantation
- CMCT, central motor conduction time
- FDI, first dorsal interosseous
- MEP, motor evoked potential
- SSEP, short latency somatosensory evoked potential
- TCT, total conduction time
- TMS, transcranial magnetic stimulation
- VEP, visual evoked potential
- VLCFA, very long chain fatty acid
- WAIS-R, Wechsler Adult Intelligence Scale Revised
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- ALD, adrenoleukodystrophy
- BAEP, brain stem auditory evoked potential
- BMT, bone marrow transplantation
- CMCT, central motor conduction time
- FDI, first dorsal interosseous
- MEP, motor evoked potential
- SSEP, short latency somatosensory evoked potential
- TCT, total conduction time
- TMS, transcranial magnetic stimulation
- VEP, visual evoked potential
- VLCFA, very long chain fatty acid
- WAIS-R, Wechsler Adult Intelligence Scale Revised
Footnotes
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Competing interests: none declared.