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As it is well known, endorphin levels change in different circumstances, for example, in injury, illness, or as a result of circadian influences, among
others.[1-7] It would be helpful to know which was the primary stimulus for
endorphin level changes in MS patients. Perhaps a further experiment can
show that it is or is not circadian.
(1) Covelli V,
Massari F, Falla...
(1) Covelli V,
Massari F, Fallacara C, Munno I, Jirillo E, Savastano S,
Tommaselli AP, Lombardi G. Interleukin-1
beta and beta-endorphin circadian rhythms are inversely
related in normal and stress-altered sleep.
Int J Neurosci. 1992 Apr;63(3-4):299-305.
(2) Iranmanesh A,
Lizarralde G, Johnson ML, Veldhuis JD. Circadian,
ultradian, and episodic release of beta-endorphin in men,
and its temporal coupling with cortisol.J Clin
Endocrinol Metab. 1989 Jun;68(6):1019-26.
(3) Sekiya K, Nawata H, Kato K, Motomatsu T,
Ibayashi H. Diurnal rhythms of
proopiomelanocortin-derived N-terminal peptide,
beta-lipotropin, beta-endorphin and adrenocorticotropin in
normal subjects and in patients with Addison's disease and
Cushing's disease. Endocrinol Jpn. 1986 Oct;33(5):713-9.
(4) Melmed S. Series Introduction: The immuno-neuroendocrine interface. J Clin Invest, December 2001, Volume 108, Number 11, 1563-1566
(5) Barreca T, Siani C, Franceschini R, Francaviglia N, Messina
V, Perria C, Rolandi E. Diurnal beta-endorphin changes in human cerebrospinal fluid. Life Sci. 1986 Jun 16;38(24):2263-7.
(6) Shanks MF, Clement-Jones V, Linsell
CJ, Mullen PE, Rees LH, Besser GM. A study of 24-hour profiles of plasma
met-enkephalin in man. Brain Res. 1981 May 18;212(2):403-9.
(7) Gil-Ad I, Dickerman Z, Amdursky S, Laron Z.
Diurnal rhythm of plasma beta endorphin, cortisol and growth
hormone in schizophrenics as compared to control subjects.
Psychopharmacology (Berl). 1986;88(4):496-9.