Article Text
Abstract
A 68 year old woman developed oculomotor paresis shortly after metastatic progression of her melanoma was discovered. She was then immunised with the tumour antigen MAGE-3 in combination with an immunological adjuvant. During immunisation her symptoms worsened and she developed severe, predominantly proximal axonal motor neuropathy and became bedridden. IgM antibodies against gangliosides GM2, GD3, and GQ1b were detected in serum obtained two weeks before and nine weeks after the onset of symptoms. Immunohistochemically, the patient’s IgM reacted with the tumour and co-localised with GQ1b. She improved neurologically following steroid treatment and became ambulatory.
- paraneoplastic syndrome
- ophthalmoplegia
- malignant melanoma
- motor neuropathy
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Footnotes
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L Kloos is presently at the Neurology Department, Leyenburg Ziekenhuis, Den Haag, The Netherlands
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Competing interests: none declared
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