Article Text

Download PDFPDF
Assessment of the impact of the removal of cerebrospinal fluid on cerebral tissue volumes by advanced volumetric 3D-MRI in posthaemorrhagic hydrocephalus in a premature infant
  1. R W Hunt1,
  2. S K Warfield,
  3. H Wang1,
  4. M Kean2,
  5. J J Volpe3,
  6. T E Inder1
  1. 1Department of Neonatal Neurology, Royal Children’s Hospital, University of Melbourne, Australia
  2. 2Department of Medical Imaging, Royal Children’s Hospital
  3. 3Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA
  1. Correspondence to:
 Dr Terrie Inder, Department of Neonatal Neurology, Level 2, Royal Children’s Hospital, Flemington Road, Parkville, VIC 3052, Australia; 


Current clinical practice in the premature infant with posthaemorrhagic ventricular dilatation (PHVD) includes drainage of cerebrospinal fluid (CSF). This case study used advanced volumetric three dimensional magnetic resonance imaging to document the impact of CSF removal on the volume of regional brain tissues in a premature infant with PHVD. The removal of a large volume of CSF was associated with an identical reduction in CSF volume, but more dramatically with a significant increase in the regional volumes of cortical grey matter and myelinated white matter. The alterations in cerebral cortical grey matter and myelinated white matter volumes may provide insight into the established association of PHVD with deficits in cognitive and motor functions.

  • ventriculomegaly
  • lumbar puncture
  • volumetric MRI

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests: none declared