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Screening for variant Creutzfeldt-Jakob disease
  1. D A Hilton1,
  2. J W Ironside2
  1. 1Department of Histopathology, Derriford Hospital, Plymouth, UK
  2. 2CJD Surveillance Centre, Edinburgh, UK
  1. Correspondence to:
 Dr D Hilton Department of Neuropathology, Derriford Hospital, Plymouth PL6 8DH, UK; 

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The letter by Joiner et al1 describes the lack of detectable prion protein (PrP) in three of four necropsy appendix samples from vCJD cases using a combination of immunocytochemistry and western blotting, thereby questioning the value of large scale screening of appendix tissue samples as an estimate of people who may be incubating vCJD. In our original description of PrP accumulation in the appendix before the onset of symptoms …

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