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Spinal cord atrophy and disability in multiple sclerosis over four years
  1. M A Horsfield1,
  2. M Filippi2
  1. 1Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
  2. 2Neuroimaging Research Unit, Scientific Institute Ospedale S Raffaele, Via Olgettina 60, Milan, Italy
  1. Correspondence to:
 Mark A. Horsfield;

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A reproducible measure of cord area for detecting atrophy rates

It is natural to focus on spinal cord damage as a major factor in disability. Indeed, interest in the use of MRI to study the spinal cord in multiple sclerosis, and its relation to locomotor disability, has been on the increase for over 10 years. The paper by Lin et al (pp 1090–1094)1 is the first medium term follow up (four years) of spinal cord atrophy in both untreated patients and patients treated with interferon β-1a.

Initial studies of the cord concentrated on the visible lesions seen with conventional MRI, and results were …

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