Background:Chlamydophila pneumoniae has been postulated as an aetiological agent in the pathophysiology of multiple sclerosis. Previous studies show conflicting results.
Objective: To investigate patients with multiple sclerosis and other neurological diseases for evidence of past or present infection with C pneumoniae.
Methods: 19 patients with multiple sclerosis and 29 with other neurological diseases were studied. Evidence was sought for past or present infection with C pneumoniae using polymerase chain reaction (PCR) and cell culture of cerebrospinal fluid (CSF), and enzyme linked immunosorbent assay and microimmunofluorescence of serum.
Results:Cpneumoniae was grown from the CSF of one patient with multiple sclerosis. PCR was negative in all cases. Anti-chlamydial antibodies were detected in the same proportion in each group.
Conclusions: This study does not support the theory of an association between C pneumoniae and multiple sclerosis.
- multiple sclerosis
- chlamydophila pneumoniae
- MIF, microimmunofluorescence
- ELISA, enzyme-linked immunosorbent assay
- ELONA, enzyme-linked oligonucleotide assay
- PCR, polymerase chain reaction
- RFLP, restriction fragment length polymorphism
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Competing interests: none declared
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