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The longer term outcome of children born to mothers with epilepsy
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  • Published on:
    Risk of developmental delay in children born to epileptic mothers treated with antiepileptic agents
    • bertrand de Toffol, Prof Neurology
    • Other Contributors:
      • catherine Billard, bertrand de Toffol and Elisabeth Autret-Leca

    Dear Editor,

    We read the retrospective study by Adab et al [1] with interest; this paper raises the issue of risk of developmental delay in children aged 6 years and over born to epileptic mothers treated with antiepileptic agents during pregnancy. More specifically, foetal exposure to valproate could involve significant risk of impairment of verbal IQ in such children, despite no change in full scale IQ.

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    Conflict of Interest:
    None declared.
  • Published on:
    Delays caused by increased testosterone

    Dear Editor,

    I suggest the developmental delays and intellectual problems, exhibited by children of mothers who take valproate for epilepsy, are caused by increased testosterone.

    Learning disabilities have been connected with increased testosterone levels in children (Physiol Behav. 1993 Mar;53(3):583-6). Adab et al, determined that valproate increased the need for "additional educational nee...

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    Conflict of Interest:
    None declared.