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Smell testing: an additional tool for identification of adult Refsum’s disease
  1. F B Gibberd1,
  2. M D Feher1,
  3. M C Sidey1,
  4. A S Wierzbicki1,2
  1. 1Refsum’s Disease Clinic, Chelsea & Westminster Hospital, London, UK
  2. 2Department of Chemical Pathology, St Thomas’s Hospital, London, UK
  1. Correspondence to:
 Dr Michael Feher
 Refsum’s Disease Clinic, Chelsea & Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK;


Background: Adult Refsum’s disease (ARD) is characterised by the presence of retinitis pigmentosa, ataxia, deafness, sensory neuropathy, and bony changes. The diagnosis is confirmed by the presence of phytanic acidaemia. Although reduced smell function has been described in ARD, its value in the diagnosis of the condition has not been fully evaluated.

Objective: To investigate the prevalence and degree of olfactory dysfunction in patients with ARD.

Method: The olfactory function of 16 patients with ARD was assessed using the quantitative University of Pennsylvania Smell Identification Test (UPSIT).

Results: All patients had complete anosmia or grossly impaired smell function with a mean UPSIT score of 14.7 (SD 4.7) (normal>34) despite having been treated with an appropriate diet for a median of 15 years (range 1–25).

Conclusions: Identification of ARD patients can be facilitated by using the UPSIT in combination with the presence of retinitis pigmentosa, even if they have no neurological or bony features. Phytanic acid screening should be performed in any patient manifesting these two signs.

  • AMAC, α-methyl acyl-CoA racemase deficiency
  • ARD, adult Refsum’s disease
  • UPSIT, University of Pennsylvania Smell Identification Test
  • Refsum’s disease
  • phytanic acid
  • smell
  • anosmia
  • screening
  • retinitis pigmentosa
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  • This work was funded in part by the European Community Biomed 5 grant QLG3-CT-2002-00696 to the investigators.

  • Competing interests: none declared

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