Background: Mitochondrial disorders may affect basal ganglia function. In addition, decreased activity of complex I of the mitochondrial electron transport chain has been linked to the pathogenesis of dopaminergic cell loss in Parkinson’s disease.
Objective :To investigate the dopaminergic system in patients with known mitochondrial disorders and complex I deficiency.
Methods: Dopamine transporter density was studied in 10 female patients with mitochondrial complex I deficiency by 123I-FP-CIT (N-β-fluoropropyl-2β-carbomethyl-3β-(4-iodophenyl)-nortropane) SPECT.
Results: No differences in 123I-FP-CIT striatal binding ratios were observed and no correlation of the degree of complex I deficiency and striatal binding ratios could be detected.
Conclusions: These data argue against the possibility that mitochondrial complex I deficiency by itself is sufficient to elicit dopaminergic cell loss.
- CPEO, chronic progressive external ophthalmoplegia
- DAT, dopamine transporter
- SPECT, single photon emission computed tomography
- 123 I-FP-CIT SPECT
- mitochondrial disorders
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Competing interests: KT has been paid by Amersham Health for speaking and organising educational seminars. He also has a consultancy contract and has been reimbursed for attending conferences organised by the company. The department receives research funds from the company.