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Drug induced pseudolymphoma secondary to ethosuximide
  1. M R Masruha1,
  2. C M Marques1,
  3. L C P Vilanova1,
  4. M T de Seixas Alves2,
  5. M F P Peres3,
  6. M G Rodrigues4
  1. 1Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo, Brazil
  2. 2Department of Pathology, Federal University of São Paulo
  3. 3Research and Teaching Institute, Albert Einstein Hospital, São Paulo
  4. 4Department of Paediatrics, Federal University of Espírito Santo, Espírito Santo, Brazil
  1. Correspondence to:
 Dr Marcelo Rodrigues Masruha
 Division of Child Neurology, Department of Neurology and Neurosurgery, Botucatu Street 720, Federal University of São Paulo, São Paulo 04023-9000, Brazil;

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Ethosuximide is an antiepileptic succinimide, widely used in the treatment of absence seizures. Haemopoietic complications associated with the administration of this drug have included leucopenia, agranulocytosis, pancytopenia with or without bone marrow suppression, and eosinophilia.1 We report a patient with pseudolymphoma induced by ethosuximide, a complication never reported previously.

Case report

A 12 year old boy presented with a two months history of fever, weight loss (3 kg), and non-painful swellings on the neck, axillae, and both inguinal regions. The patient had been on ethosuximide for three months for childhood absence epilepsy. It was being given at a dose of 30 mg/kg/day, in three divided doses, and the seizures had been under reasonable control.

Physical examination on presentation revealed enlarged lymph nodes on the both sides of the neck, axillae, and inguinal regions. All the nodes were non-tender, firm, measuring 1 to …

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  • Competing interests: none declared