Article Text
Short report
Multiple pathologies in a patient with a progressive neurodegenerative syndrome
Abstract
A woman presenting with levodopa responsive Parkinsonism developed rapidly progressive bulbar signs, quadriparesis, and upper and lower motor neurone signs. At necropsy, she was found to have three pathological diagnoses: amyotrophic lateral sclerosis, Parkinson’s disease, and abundant tau-positive argyrophilic neuritic pathology, known as argyrophilic grain disease. This case raises the possibility that three distinct neuropathological diagnoses share a common aetiology.
- AGD, argyrophilic grain disease
- ALS, amyotrophic lateral sclerosis
- DLB, dementia with Lewy bodies
- MSA, multiple system atrophy
- PSP, progressive supranuclear palsy
- α-synuclein
- amyotrophic lateral sclerosis
- progressive neurodegeneration
- Parkinson’s disease
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Footnotes
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Competing interests: none declared