Background and Objective: Specific screening tests to detect post-stroke dementia are lacking. We recently reported that an adaptation of the Cambridge Cognitive Examination (CAMCOG), the Rotterdam-CAMCOG, had excellent sensitivity and specificity for detecting post-stroke dementia. In this study, we externally validated the diagnostic accuracy of the R-CAMCOG in a new, representative cohort of stroke patients.
Methods: The R-CAMCOG and an extensive neuropsychological examination were administered, independently of each other, in 121 patients aged 55 and over with a stroke in the preceding three to nine months. The gold standard diagnosis of dementia was based on the results of the extensive neuropsychological examination, clinical presentation, and information from a close relative, as well as DSM-IV criteria.
Results: Of the 121 patients, 35 had dementia (29%). The diagnostic accuracy at the pre-specified cut-off point of 33/34 was established through receiver operating characteristic (ROC) analyses (sensitivity 66%, specificity 94%). At a cut-off point of 36/37 sensitivity would be 83% and specificity 78%.
Conclusion: The R-CAMCOG is a useful screening tool for post-stroke dementia in a clinical setting.
- CAMCOG, Cambridge Cognitive Examination
- R-CAMCOG, Rotterdam-CAMCOG
- TIA, transient ischaemic attack
- post-stroke dementia
- vascular dementia
- diagnostic testing
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The study “Screening for dementia with the R-CAMCOG in patients with a recent stroke” is supported by a grant of the College voor Zorgverzekeringen (Dutch Board of Health Insurance).
Competing interests: none declared
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