Article Text

Download PDFPDF
Vitamin B-12, serum folate, and cognitive change between 11 and 79 years
  1. J M Starr1,
  2. A Pattie2,
  3. M C Whiteman2,
  4. I J Deary2,
  5. L J Whalley3
  1. 1Geriatric Medicine unit, Royal Victoria Hospital, Craigleith Road, Edinburgh, EH4 2DN, UK
  2. 2Psychology, School of Philosophy, Psychology and Language Sciences, University of Edinburgh
  3. 3Department of Mental Health, University of Aberdeen, Clinical Research Centre, Cornhill Royal Hospital, Aberdeen, UKDr John M Starr;

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    A recent Cochrane review reported that although vitamin B-12 deficiency is known to be associated with cognitive impairment in old age, benefits of supplementation on mental ability are unclear.1 The situation is similar to that for blood pressure, in which hypertension is associated with neuropsychological deficits in adulthood but cognitive outcomes of lowering blood pressure in randomised controlled trials are equivocal. We found that for blood pressure, the limited effect of intervention is partly explained by the relation between childhood IQ and adult blood pressure—children with higher IQs had lower mid-life blood pressures.2 As approximately 50% of the variance in adult IQ is explained by childhood IQ, studies failing to account for “pre-morbid” mental ability are likely to overestimate the association between adult IQ and blood pressure. Previously we reported significant relations between various tests of mental ability in old age and vitamin B-12 and folic acid concentrations in the blood.3 We now describe the association between vitamin B-12 and serum folate and lifetime change in mental ability using the same cognitive test at age 11 and age 79.

    As reported more fully elsewhere,4 the 1932 Scottish Mental Survey (SMS1932) measured the mental ability of almost all (n = 87 498) children born in 1921 and attending Scottish schools on 1 …

    View Full Text


    • Competing interests: none declared