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The effect of subthalamic nucleus stimulation on kinaesthesia in Parkinson’s disease
  1. M Maschke1,2,
  2. P J Tuite3,
  3. K Pickett1,
  4. T Wächter3,4,
  5. J Konczak1,3
  1. 1Sensorimotor Control Laboratory, Division of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA
  2. 2Department of Neurology, University Duisburg-Essen, Essen, Germany
  3. 3Department of Neurology, University of Minnesota
  4. 4Brain Sciences Center, Minneapolis VAMC, University of Minnesota
  1. Correspondence to:
 Dr Matthias Maschke
 Department of Neurology, University Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany; matthias.maschkeuni-essen.de

Abstract

Background: Parkinson’s disease is accompanied by deficits in passive motion and limb position sense.

Objective: To investigate whether deep brain stimulation of the subthalamic nucleus (STN-DBS) reverses these proprioceptive deficits.

Methods and results: A passive movement task was applied to nine patients with Parkinson’s disease and bilateral chronic STN-DBS and to seven controls. Thresholds for 75% correct responses were 0.9° for controls, 2.5° for Parkinson’s disease patients when stimulation was OFF, and 2.0° when stimulation was ON.

Conclusions: STN-DBS improves kinaesthesic deficits in Parkinson’s disease, but does not lead to a full recovery of proprioceptive function.

  • CVLT, California verbal learning test
  • MMSE, mini-mental state examination
  • STN-DBS, deep brain stimulation of the subthalamic nucleus
  • WAIS, Wechsler adult intelligence scale
  • WASI, Wechsler abbreviated scale of intelligence
  • WMS, Wechsler memory scale
  • deep brain stimulation
  • Parkinson’s disease
  • kinaesthesia
  • subthalamic nucleus

https://doi.org/10.1136/jnnp.2004.047324

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    Footnotes

    • Competing interests: none declared