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Neurodegenerative disorders: Parkinson’s disease and Huntington’s disease
  1. S M Hague,
  2. S Klaffke,
  3. O Bandmann
  1. Academic Neurology Unit, Division of Genomic Medicine, University of Sheffield, UK
  1. Correspondence to:
 Dr Oliver Bandmann
 Academic Neurology Unit, E Floor Medical School, Beech Hill Road, Sheffield S10 2RX, UK;


Parkinson’s disease and Huntington’s disease are both model diseases. Parkinson’s disease is the most common of several akinetic-rigid syndromes and Huntington’s disease is only one of an ever growing number of trinucleotide repeat disorders. Molecular genetic studies and subsequent molecular biological studies have provided fascinating new insights into the pathogenesis of both disorders and there is now real hope for disease modifying treatment in the not too distant future for patients with Parkinson’s disease or Huntington’s disease.

  • A-S, α-synuclein
  • COX2, cyclo-oxygenase 2
  • CBP, CREB binding protein
  • MPTP, 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine
  • genetics
  • Huntington’s disease
  • Parkinson’s disease

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  • Competing interests: none declared