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Normal memory and no confabulation after extensive damage to the orbitofrontal cortex
  1. T Fujii1,
  2. M Suzuki1,
  3. K Suzuki1,
  4. H Ohtake2,
  5. T Tsukiura3,
  6. R Miura4
  1. 1Department of Behavioural Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan; fujii@mail.tains.tohoku.ac.jp
  2. 2Department of Internal Medicine and Therapeutics, Yamagata University School of Medicine, Yamagata 990-2331, Japan
  3. 3Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba 305-8568, Japan
  4. 4Department of Psychiatry, Chubu National Hospital, Nagoya 474-8511, Japan

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    Subarachnoid haemorrhage caused by the rupture of an anterior communicating artery (ACoA) aneurysm is often followed by amnesia, confabulation, and personality change including social decision making.1–3 However, the regions responsible for each symptom have not been determined conclusively. We describe a patient who showed personality change, but neither memory impairment nor confabulation, after extensive damage to the bilateral orbitofrontal cortex demonstrated by magnetic resonance imaging, providing evidence that the destruction of the medial orbitofrontal cortex alone cannot cause amnesia and confabulation.

    Case report

    The patient was a 45 year old, right handed man with a 16th grade education. He was not an apathetic person and worked hard as a manager before the onset. His past medical history was unremarkable and he had no medication. He had sudden onset of headache, became unconscious, and was admitted to an emergency hospital. Brain computed tomography showed a subarachnoid haemorrhage in the cisterns around the brainstem, longitudinal cerebral fissure, and bilateral Sylvian fissure caused by a ruptured aneurysm of the ACoA. On the same day, he underwent an operation to repair the ruptured aneurysm. There were slight brain oedema and vasospasm (four to 10 days). He did not become delirious, agitated, or suspicious. He had 200 mg of phenitoin each day to prevent secondary seizures. His family noted that he showed mild anterograde amnesia, which improved over two months, but no retrograde amnesia.

    The patient was discharged home after three months. He began working again …

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    Footnotes

    • Competing interests: none declared

    • The patient gave informed consent for this letter to be published.