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Ischaemic and haemorrhagic strokes may have a common pathogenesis
The risk of intracerebral haemorrhage (ICH) is increased in patients with ischaemic cerebrovascular disease and vice versa.1 Risk factors shared by both stroke subtypes, such as hypertension, age, and smoking, partly explain this observation. While some researchers stress that most ischaemic stroke subtypes have similar risk factor profiles, one can go further and claim that most strokes (ischaemic and haemorrhagic) are the result of a common final pathway: arterial wall damage with accumulation of abnormal cells and proteins, inflammation, molecular changes, and eventual breakdown of the intima and media. Hypertensive cerebral arteriolopathy and cerebral amyloid angiopathy are examples where ischaemic and haemorrhagic brain damage frequently coexist. Leukoaraiosis and microbleeds may both be markers of a single disease process …
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Competing interests: none declared