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Diffuse lesion in the splenium of the corpus callosum in patients with methyl bromide poisoning
  1. K Kang1,
  2. Y-M Song2,
  3. K D Jo3,
  4. J-K Roh4
  1. 1Department of Neurology, Asan Mental Hospital, Asan, Republic of Korea
  2. 2Department of Neurology, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Republic of Korea
  3. 3Department of Neurology, Kangnung Asan Hospital, University of Ulsan College of Medicine, Kangnung, Republic of Korea
  4. 4Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
  1. Correspondence to:
 Dr Jae-Kyu Roh
 Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, 28, Yeongon-dong, Jongno-gu, Seoul, 110-744, Republic of Korea; rohjk{at}

Statistics from

Imaging abnormalities of the splenium of the corpus callosum (SCC) are uncommon but have been described in various clinical conditions such as Marchiafava-Bignami disease, trauma, infectious diseases, acute disseminated encephalomyelitis, epilepsy, altitude sickness, hypoglycaemia, electrolyte abnormalities, leukodystrophy, and infarction, and following radiation therapy and chemotherapy.1,2 We have detected a diffuse lesion in the SCC of two patients with methyl bromide intoxication.

Case report 1

The first case involved a previously healthy 31 year old man. He had worked in a fumigating plant spraying strawberries for 1 month prior to admission. Strawberries were fumigated with methyl bromide for 2 h in an enclosed room. After fumigation, the room was ventilated for 10 min with electric fans. Thereafter, the subject transferred the fumigated fruits to a warehouse. He worked for 3 h every other day. The subject reported experiencing intermittent nausea, dizziness, and ambulatory difficulty. On the day of hospital admission, the patient complained of general weakness, developed paraesthesia in the hands and feet, and was unable to recall daily events. He was admitted to the nearest hospital. The patient exhibited urinary incontinence, talked to himself, and was unable to walk unaided. He was transferred to our hospital 2 days later. Upon examination, all of the patient’s vital signs proved normal. However, he attempted to grab phantom objects in the air, sucked his fingers, and had difficulty …

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  • Patient details are published with consent

  • Competing interests: none declared

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