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Beck Depression Inventory is a useful screening tool for major depressive disorder in Gilles de la Tourette syndrome
  1. A H Snijders1,
  2. M M Robertson2,
  3. M Orth3
  1. 1Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
  2. 2Department of Mental Health Sciences, University College London, London, UK
  3. 3Raymond Way Unit, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
  1. Correspondence to:
 Dr M Orth
 Department of Neurology, Universitätsklinikum Eppendorf, Martinistr. 20, 20246 Hamburg, Germany; m.orth{at}


This study determined the prevalence of and factors associated with comorbid major depressive disorder (MDD) in patients with Gilles de la Tourette syndrome (GTS). How a simple self-report instrument, the Beck Depression Inventory (BDI), correlates with clinical assessment of comorbid MDD in this population was assessed. In a continuous sample of 114 adult patients with GTS, assessed clinically using the Diagnostic and Statistical Manual of Mental Disorders-IV criteria, 26 (23%) patients met criteria for MDD; more severe tics as measured with the Yale Global Tic Severity Scale, conduct disorder in childhood or higher age at the time of assessment were associated with MDD. The BDI score had a high negative predictive value for diagnosis of MDD, but a low positive predictive value. Using the BDI as a screening tool for comorbid MDD in patients with GTS is suggested.

  • BDI, Beck Depression Inventory
  • DSM-IV, Diagnostic and Statistical Manual for Mental Disorders-IV
  • GTS, Gilles de la Tourette syndrome
  • LOI, Leyton Obssesional Inventory
  • MDD, major depressive disorder
  • STAI, Spielberger State Trait Anxiety Index

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  • Published Online First 24 February 2006

  • Competing interests: None declared.