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Thrombolysis in patients older than 80 years with acute ischaemic stroke: Canadian Alteplase for Stroke Effectiveness Study
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Other responses

  • Published on:
    Thrombolysis for acute stroke: what about the actual impact of patients older than 80 years?
    • Giovanni Orlandi, Neurologist
    • Other Contributors:
      • Alberto Chiti, Simona Fanucchi, Simone Gallerini, Chiara Sonnoli and Nicola Morelli.

    Dear Editor,

    We read with great interest the study by Sylaja et al. [1] evaluating the clinical characteristics and complications and the predictors of outcome after intravenous tPA treatment in patients aged >/= 80 years. The authors found that age >/= 80 years was an independent predictor of outcome, but it was not associated with an increased risk of symptomatic intracerebral haemorrhage. Taking into acc...

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    Conflict of Interest:
    None declared.
  • Published on:
    Risk and benefit of tPA in elderly ischemic stroke patients
    • John M Reid, Neurologist
    • Other Contributors:
      • Gordon J Gubitz, and Stephen J Phillips.

    Dear Editor,

    In the recent article by Sylaja et al [1] patients from the Canadian Alteplase for Stroke Effectiveness Study [2] treated with tPA aged >/= 80 years had a symptomatic intracranial haemorrhage (SICH) rate of 4.4% compared to 4.6% in patients <80 years old. These data are encouraging. The authors mention patient selection bias may be a factor in their results, however we wonder whether there may...

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    Conflict of Interest:
    None declared.