Article Text

Download PDFPDF
Insular cortical ischaemia does not independently predict acute hypertension or hyperglycaemia within 3 h of onset
  1. J A Pettersen1,
  2. J H W Pexman1,
  3. P A Barber1,
  4. A M Demchuk1,
  5. A M Buchan2,
  6. M D Hill1
  1. 1Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
  2. 2Department of Clinical Geratology, University of Oxford, Oxford, UK
  1. Correspondence to:
 Michael D Hill
 Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada; michael.hill{at}


Objectives: To test the hypothesis that insular cortical ischaemia is associated with acute hypertension and hyperglycaemia.

Methods: From the Canadian Activase for Stroke Effectiveness Study, which included only patients treated with thrombolysis hyperacutely (ie, within 3 h of onset of stroke), 966 patients were identified with ischaemia affecting (n = 685), or sparing (n = 281), the insular cortex. Demographic and clinical data, pretreatment indices of blood pressure, blood glucose, atrial fibrillation, and clinical imaging and outcome measures were compared between the two groups. Multivariable linear regression was used to assess predictors of systolic blood pressure and glucose levels before thrombolysis.

Results: Pretreatment hypertension (p = 0.009), but not hyperglycaemia (p = 0.32), was predicted by insular ischaemia in univariable linear regression analyses. After adjusting for other factors, however, insular cortical ischaemia was not found to be an independent predictor for acute hypertension or hyperglycaemia.

Conclusions: Raised blood pressure or serum glucose levels in hyperacute (<3 h) cerebral ischaemia is not independently predicted by insular involvement. Several hours are required for sympathetic manifestations of insular ischaemia to evolve.

  • ASPECTS, Alberta Stroke Program Early CT Score
  • NIHSS, National Institute of Health Stroke Scale
  • SBP, systolic blood pressure

Statistics from


  • See Editorial Commentary, p 813

  • Competing interests: None declared.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles