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Primary sciatic nerve lymphoma: a case report and review of the literature
  1. M J L Descamps1,
  2. L Barrett1,
  3. M Groves3,
  4. L Yung4,
  5. R Birch2,
  6. N M F Murray1,
  7. D C Linch4,
  8. M P T Lunn1,
  9. M M Reilly1
  1. 1Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
  2. 2Peripheral Nerve Injury Unit, Royal National Orthopaedic Hospital NHS Trust, Brockley Hill, Stanmore, Middlesex, UK
  3. 3Department of Molecular Neurosciences, Institute of Neurology, Queen Square
  4. 4Haematology Department, University College, London
  1. Correspondence to:
 M M Reilly
 National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK;m.reilly{at}


A patient with primary B cell non-Hodgkin’s lymphoma of the sciatic nerve is described. He presented with neuropathic symptoms in the left leg, initially diagnosed as tarsal tunnel syndrome. Magnetic resonance imaging (MRI) identified the abnormality in the sciatic nerve. A fascicular biopsy of the sciatic nerve showed a diffuse large B cell non-Hodgkin’s lymphoma. The patient was treated with chemotherapy and rituximab (anti-CD20 monoclonal antibody). Four months later he was in remission, and remains so 48 months from presentation. Primary lymphoma of single peripheral nerves may be a unique subtype of extranodal lymphoma, which usually follows an aggressive course and has a variable response to current therapeutic strategies. MRI is useful, alongside electrophysiological studies, in patients with atypical peripheral nerve symptoms.

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  • Competing interests: None.

  • Informed consent was obtained for publication of the patient’s details described in this report.