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Relapsing hypocupraemic myelopathy requiring high-dose oral copper replacement
  1. C I Prodan1,
  2. S S Bottomley2,
  3. N R Holland4,
  4. S E Lind3
  1. 1Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
  2. 2Department of Medicine, University of Oklahoma Health Sciences Center
  3. 3Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado, USA
  4. 4Neurology Specialists of Monmouth County, West Longbranch, New Jersey, USA
  1. Correspondence to:
 C I Prodan
 711 S.L. Young Boulevard, PPOB, Suite 215, Oklahoma City, OK 73104, USA; calin-prodan{at}


Adult-onset copper deficiency with neurological manifestations is a newly recognised syndrome. Long-term oral copper replacement therapy has been the mainstay of treatment in the literature. A case of relapsing hypocupraemic myelopathy responsive to increased doses of copper replacement is reported. Standard doses of copper may not be sufficient for all patients.

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  • Competing interests: None declared.

  • Informed consent was obtained for publication of the patient’s details described in this report.