Article Text

Download PDFPDF
Neurogenic pulmonary oedema in a patient with leptomeningeal carcinomatosis
  1. R Dammers1,2,
  2. M J van den Bent1
  1. 1Department of Neuro-Oncology, Dr Daniël den Hoed Cancer Clinic, Rotterdam, The Netherlands
  2. 2Department of Neurosurgery, Erasmus Medical Centre, Rotterdam
  1. Correspondence to:
 Dr Martin J van den Bent
 Department of Neuro-Oncology, Dr Daniël den Hoed Cancer Clinic, PO Box 5201, 3008 AE Rotterdam, The Netherlands; m.vandenbent{at}

Statistics from

We present the case of a patient with leptomeningeal carcinomatosis from a primary breast adenocarcinoma. On admission to hospital, she developed neurogenic pulmonary oedema due to increased intracranial pressure (ICP), as confirmed by lumbar puncture. Tapping of the CSF resulted in abrupt relief of the clinical sequelae.

A woman in her late 40s, with a medical history of breast adenocarcinoma, for which she underwent a modified radical mastectomy with axillar lymph node resection, was admitted to our hospital for intrathecal chemotherapy. Just 1 month earlier, she underwent craniotomy for a solitary metastatic intracerebral lesion in the left frontal lobe. After this uneventful procedure, she continuously complained of drowsiness, nausea and vomiting. A CT scan showed enhancement of cerebral and cerebellar sulci, typical of leptomeningeal metastasis.

This diagnosis prompted admittance to our …

View Full Text


  • Competing interests: None declared.

  • Informed consent was obtained for publication of the patient’s details in this report.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.