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Letter
Patients characteristics with cholinesterase inhibitor resistant hallucinations in dementia with Lewy bodies
  1. Florence Lebert,
  2. Florence Pasquier
  1. Memory Centre, University Hospital of Lille, Lille, France
  1. Dr Florence Lebert, Centre de la Mémoire, Hôpital Roger Salengro CHRU, 59037 Lille, France; f-lebert{at}chru-lille.fr

https://doi.org/10.1136/jnnp.2007.119446

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    Cholinesterase inhibitors (ChEIs) are effective in treating visual hallucinations (VH) in dementia with Lewy bodies (DLB). Nonetheless, approximately 35% of patients treated with rivastigmine showed no significant improvement according to the psychosis subscores of the Neuropsychiatry Inventory (NPI).1 We conducted an observational study in our memory clinic and we report the characteristics of patients who showed resistant hallucinations (RH) to ChEIs.

    Methods

    We carried out an observational study of outpatients with DLB with hallucinations treated with ChEIs over 4 years. Probable DLB was diagnosed according to the second consensus criteria, and the severity of dementia was assessed using the Mini-Mental State Examination (MMSE) score. We excluded patients who required concomitant medications other than ChEIs that influence hallucinations or if they were treated with antipsychotics. Episodes of …

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    Footnotes

    • Funding: This work was supported by grant EA 2691.

    • Competing interests: None.