To save their patients from dialysis and transplantation, neurologists need simply remain alert to the possibility of renal failure, particularly in the context of systemic disease, diabetes, sepsis and drugs. Of the numerous territories shared by our respective specialities, we outline a pragmatic approach to the diagnosis and treatment of the vasculitides, underpinned by knowing which questions to ask, equally importantly when to ask them, and in the art of obtaining a tissue diagnosis. We consider the current evolving trial evidence that directs the usage of a growing arsenal of therapies in the induction and maintenance stages of vasculitis treatment, and extend this consideration to Lupus and Sjogren’s.
- ACE, angiotensin converting enzyme
- ANCA, antineutrophil cytoplasmic antibodies
- BAFF, B cell activating factor or BLyS
- IVIg, intravenous immunoglobulin
- NPSLE, neuropsychiatric systemic lupus erythematosus
- TNF, tumour necrosis factor
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