Article Text

Download PDFPDF
Regional variations in the prevalence of multiple sclerosis in French farmers
  1. Sandra Vukusic1,
  2. Vincent Van Bockstael2,
  3. Sophie Gosselin2,
  4. Christian Confavreux1
  1. 1Service de Neurologie A and EDMUS Coordinating Centre, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France; INSERM U 842, Lyon, France; Université de Lyon, Lyon, France; Université Lyon 1, Lyon, France
  2. 2Mutualité Sociale Agricole, Caisse Centrale, Bagnolet, France
  1. Correspondence to:
 Dr Sandra Vukusic
 Service de Neurologie A, Hôpital Neurologique Pierre Wertheimer, 59 Boulevard Pinel, 69677 Lyon Bron Cedex, France; sandra.vukusic{at}


Background: Studies on the prevalence of multiple sclerosis have been carried out worldwide, showing a heterogeneous distribution between countries and even between the different regions of the same country.

Methods: We estimated the regional and national prevalence of multiple sclerosis in France on 1 January 2003, based on the computerised database of the national farmer health insurance system (“Mutualité Sociale Agricole”).

Results: There were 2667 cases of multiple sclerosis registered on the prevalence date, out of 4 098 477 affiliates. After standardisation on age, estimates for the national prevalence of multiple sclerosis in French farmers were 65.0 per 100 000 inhabitants (95% confidence interval 62.5 to 67.5), 41.9 per 100 000 in men (39.1 to 44.7) and 96.3 per 100 000 in women (92.0 to 100.6). The prevalence of multiple sclerosis was significantly higher in the north eastern regions (approximately 100 per 100 000 inhabitants) compared with the south western regions (around 50 per 100 000 inhabitants).

Conclusion: Our study is the first to evaluate the overall prevalence of multiple sclerosis in France and its 22 regions using the same methodology. Our results may be generalised to the whole French population as there is no convincing evidence of an increased or decreased susceptibility to multiple sclerosis among farmers or persons living in the countryside. This places France among the countries of medium to high prevalence. Confirming the uneven distribution of multiple sclerosis that correlates with latitude, raises once more the question of the role of genetic and environmental factors in the susceptibility to multiple sclerosis.

  • ALD, Affections de Longue Durée
  • MS, multiple sclerosis

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Published Online First 13 February 2007

  • Competing interests: None.