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Visual recognition memory differentiates dementia with Lewy bodies and Parkinson’s disease dementia
  1. K Mondon1,
  2. A Gochard2,
  3. A Marqué1,
  4. A Armand1,
  5. D Beauchamp1,
  6. C Prunier3,
  7. D Jacobi4,
  8. B de Toffol2,
  9. A Autret2,
  10. V Camus5,
  11. C Hommet6
  1. 1CMRR du Centre et Service de Neurologie, Université François Rabelais, CHRU Tours, Tours, France
  2. 2Service de Neurologie, Université François Rabelais, CHRU de Tours, Tours, France
  3. 3Service de Médecine Nucléaire, INSERM U 619, Université François Rabelais, CHRU Tours, Tours, France
  4. 4INSERM, CIC 202, Tours, France
  5. 5Clinique Psychiatrique Universitaire, Université François Rabelais, CHRU Tours, Tours, France
  6. 6CMRR du Centre INSERM U 619, Université François Rabelais, CHRU Tours, Tours, France
  1. Correspondence to:
 Dr K Mondon
 Service de Neurologie, Hôpital Bretonneau, 37044 Tours Cedex, France; karl.mondon{at}med.univ-tours.fr

Abstract

Objective: To compare cognitive impairments in dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), to discriminate between the two entities.

Methods: 10 DLB and 12 PDD consecutive patients performed a neuropsychological battery designed to assess several cognitive domains: verbal and visual memory (Delayed Matching to Sample (DMS)-48), language, gnosia, praxia and executive functions.

Results: DLB patients had poorer performances in orientation (p<0.05), Trail Making Test A (p<0.05) and reading of names of colours in the Stroop Test (p<0.05). Their scores were also lower in the visual object recognition memory test (DMS-48), in both immediate (p<0.05) and delayed recognition (p<0.05). No differences were observed in the other tests.

Conclusion: Despite global similarities in cognitive performances between DLB and PDD patients, we observed important differences: in particular, DMS-48, a test of visual object recognition memory and visual storage capacity, was poorer in DLB patients.

  • DLB, dementia with Lewy bodies
  • DMS, Delayed Matching to Sample
  • MMSE, Mini-Mental State Examination
  • PDD, Parkinson’s disease dementia
  • ROC, receiver operator characteristic
  • UPDRS, Unified Parkinson’s Disease Rating Scale

http://dx.doi.org/10.1136/jnnp.2006.104257

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    Footnotes

    • Published Online First 6 February 2007

    • Competing interests: None.

      Received 10 August 2006

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    Copyright 2007 Journal of Neurology Neurosurgery and Psychiatry