Article Text

Download PDFPDF
Spontaneous recovery of dermatomyositis and unspecified myositis in three adult patients
  1. J van de Vlekkert1,
  2. J E Hoogendijk2,
  3. C J M Frijns2,
  4. M de Visser1
  1. 1
    Department of Neurology, Academic Medical Centre, University of Amsterdam, The Netherlands
  2. 2
    Rudolf Magnus Institute for Neuroscience, Department of Neurology, University Medical Centre Utrecht, The Netherlands
  1. J van de Vlekkert, Academic Medical Centre, Department of Neurology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; j.vandevlekkert{at}


Dermatomyositis (DM), polymyositis and unspecified myositis are idiopathic inflammatory myopathies in which prednisone is usually started as soon as the diagnosis has been established. Therefore, little is known about the natural history of these diseases and spontaneous recovery may escape attention. Here, we present three patients who achieved remission without administration of immunosuppressants. In these three patients, treatment was not started because of spontaneously improving symptoms and signs during the diagnostic process. After 3–5 years, all patients are still free of muscle weakness. These case reports demonstrate that spontaneous long lasting remission can occur in a small proportion of patients with subacute onset idiopathic inflammatory myopathies. In some patients, immunosuppressive treatment with the risk of serious side effects can perhaps be omitted. However, close and frequent monitoring is required in these instances.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Funding: This study was supported by a grant from the Prinses Beatrix Fonds, The Hague, The Netherlands.

  • Competing interests: None.