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Relapsing demyelinating disease affecting both the central and peripheral nervous systems
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  • Published on:
    Demyelinating peripheral neuropathy and relapsing central demyelination:do we need more splitting ?
    • Giuliana Galassi, Medical Doctor, Attending Neurologist
    • Other Contributors:
      • Alessandra Ariatti, Francesca Girolami, Elisa Merelli, Patrizia Sola

    Autoimmune diseases are caused by aberrant response of immune system directed against triggering epitopes.(1)Coincidental occurrence of multiple autoimmune disorders in given patient suggests either common or similar pathogenetic mechanisms.(1)The concept of molecular mimicry hold that an agent may share epitopic determinants with nervous system tissues and incites immune responses. Chronic inflammatory demyelinating po...

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    Conflict of Interest:
    None declared.
  • Published on:
    Combined central and peripheral relapsing demyelination
    • Sabrina Ravaglia, MD, PhD
    • Other Contributors:
      • Arrigo Moglia, Mauro Ceroni, Enrico Marchioni

    Dear Editor,

    Zephir et al. (1) report on five patients with a syndrome of combined central and peripheral demyelination, characterized by (i) immunological aetiology, proved by CSF findings, nerve biopsy examination, and response to immune treatments; and (ii) recurrent disease course, with central nervous system (CNS) involvement apparently preceding the onset of peripheral nervous system (PNS) damage by severa...

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    Conflict of Interest:
    None declared.