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Deficiency of mitochondrial DNA polymerase γ (POLG), which is responsible for mtDNA replication and repair, causes mitochondrial diseases including autosomal dominant progressive external ophthalmoplegia (PEO),1 childhood hepato-encephalopathy (Alpers–Huttenlocher syndrome), adult-onset spinocerebellar ataxia, and sensory nerve degeneration with dysarthria and ophthalmoparesis (SANDO).2 3
Two siblings of non-consanguineous healthy Vietnamese parents were normal until childhood (fig 1A,B).
Patient II.2, the 27-year-old male, developed from the age of 15 progressive cerebellar ataxia, neuropathy, restless legs syndrome, on two occasions a transient left hemihypesthesia and four focal myoclonic epileptic seizures and received lamotrigine. He became wheelchair-bound at 22 because of severe ataxia. By 25, he developed dysphagia and weight loss. Muscle strength was preserved. No external ophthalmoplegia or cognitive deficits occurred. After discontinuing lamotrigine, he exhibited grand maux, requiring combination treatment. He became anxious and complained of migrainous headaches and abdominal pain. Soon after, he died after prolonged status epilepticus.
Lactate-ischaemia ergometry at age 20 was unremarkable. In serum, lactate and CK (244 U/l) were mildly elevated. In CSF, …
Funding Department of Neurology, Charité University Medicine Berlin, Helmholtz Gemeinschaft für Forschungseinrichtung. Telethon-Italy no GGP07019.
Competing interests None.
Patient consent Obtained from the patient's family.
Provenance and Peer review Not commissioned; externally peer reviewed.
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