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Retinal microvascular abnormalities and stroke: a systematic review
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  • Published on:
    Resonse to e-letter by Rogers et al.
    • Fergus Doubal, Research Fellow
    • Other Contributors:
      • Joanna Wardlaw

    Dear Editor,

    Rogers et al. make several points. The primary aim of our review was to search in a systematic manner for associations between retinal microvascular abnormalities and stroke subtypes and thus provide clues to the microvascular pathophysiology of lacunar stroke. We aimed to include all relevant studies (not just the large epidemiological ones), carefully evaluate clinical and retinal features for c...

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    Conflict of Interest:
    None declared.
  • Published on:
    Methodological flaws in meta-analysis may lead to misleading conclusions
    • Sophie L. Rogers, Epidemiologist
    • Other Contributors:
      • Elaine W. Chong, and Tien Y. Wong

    Dear Editor,

    We are writing in response to the meta-analysis by Doubal, Hokke and Wardlaw “Retinal Microvascular Abnormalities and Stroke – A Systematic Review” published online on 17 October 2008. While the paper is well written, the topic interesting and potentially important, we have several concerns regarding the methodological rigor of the meta-analysis.

    The fundamental issue is inappropriate poo...

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    Conflict of Interest:
    None declared.