Article Text

Download PDFPDF
Pedunculopontine nucleus stimulation induces monocular oscillopsia
  1. M U Ferraye1,
  2. P Gerardin3,
  3. B Debû1,
  4. S Chabardès1,2,
  5. V Fraix1,
  6. E Seigneuret2,
  7. J-F LeBas1,2,
  8. A-L Benabid1,2,
  9. C Tilikete3,
  10. P Pollak1,2
  1. 1
    Université Joseph Fourier, Grenoble, France and INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France
  2. 2
    Centre Hospitalier Universitaire, Grenoble, France
  3. 3
    INSERM UMR-S 864, Lyon, France and Université Lyon-I, Institut Fédératif des Neurosciences, Lyon, France
  1. Dr B Debû, Centre Hospitalier Universitaire, Pavillon de Neurologie, BP 217, 38043 Grenoble Cedex 9, France; Bettina.Debu{at}


Two patients with Parkinson’s disease with pedunculopontine nucleus (PPN) stimulation for gait impairments reported “trembling vision” during the setting of the electrical parameters, although there was no clinically observable abnormal eye movement. Oculomotor recordings revealed frequency locked voltage dependent vertical or oblique movements of the eye ipsilateral to the active contact, suggesting current spreading to the mesencephalic oculomotor fibres. These results emphasise the difficulty of stimulating this mesencephalic region.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Funding: We gratefully acknowledge the Michael J Fox Foundation and the Fondation de France for financial support. Medtronic Inc provided the implanted pulse generators for PPN stimulation. This work was promoted by the Centre Hospitalier Universitaire de Grenoble, project FREESTIPP, and the Hospices Civils de Lyon, project HCL/P/2002.303. The authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

  • Competing interests: None.

  • Ethics approval: The study was approved by the local ethics committee.